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PTEN/MMAC1/TEP1 in signal transduction and tumorigenesis

✍ Scribed by Arnaud Besson; Stephen M. Robbins; V. Wee Yong

Book ID
114430000
Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
414 KB
Volume
263
Category
Article
ISSN
1432-1327

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The PTEN/MMAC1/TEP1 gene has been isolated as a tumor suppressor gene that is altered in several types of human tumors including brain, breast, and prostate cancers. In the present study, we report PTEN/MMAC1/TEP1 alterations in human lung cancers. Intragenic homozygous deletions were detected in 6

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## Abstract ## BACKGROUND Inactivation of the tumor suppressor gene __PTEN__/__MMAC1__/__TEP1__, located on chromosome 10q23, is a common event in advanced stages of diverse human malignancies. However, the prognostic role of __PTEN__ expression in patients with hepatocellular carcinoma (HCC) has