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PTEN mutations in gliomas and glioneuronal tumors

โœ Scribed by Duerr, Eva-Maria; Rollbrocker, Britta; Hayashi, Yutaka; Peters, Nils; Meyer-Puttlitz, Birgit; Louis, David N; Schramm, Johannes; Wiestler, Otmar D; Parsons, Ramon; Eng, Charis

Book ID
110061280
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
318 KB
Volume
16
Category
Article
ISSN
0950-9232

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The PTEN (MMAC1/TEP1) tumor suppressor gene was recently isolated and mapped to human chromosome band 10q23. Homozygous deletions and mutations of PTEN were observed in cell lines and sporadic cancers of the breast, kidney, and central nervous system. Germline mutations in PTEN were recently found i