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PTEN loss in the continuum of common cancers, rare syndromes and mouse models

โœ Scribed by Hollander, M. Christine; Blumenthal, Gideon M.; Dennis, Phillip A.

Book ID
109948722
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
784 KB
Volume
11
Category
Article
ISSN
1474-1776

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## Abstract Loss of __PTEN__ is the earliest detectable genetic lesion in the endometrioid subtype of endometrial cancer (EEC), a tumor thought to be associated with an increase in unopposed estrogen activity. __Pten__^+/โˆ’^ mice develop endometrial neoplastic lesions with full penetrance, despite h