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PTEN inhibits adrenomedullin expression and function in brain tumor cells

✍ Scribed by Simone A. Betchen; Sergei Musatov; Jill Roberts; John Pena; Michael G. Kaplitt

Book ID
106480446
Publisher
Springer US
Year
2006
Tongue
English
Weight
304 KB
Volume
79
Category
Article
ISSN
0167-594X

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## Abstract Ξ”Np73 is a N‐terminally truncated p53 family member with a dominant negative function, which is upregulated in cancer. PTEN is a lipid phosphatase, which is involved in the attenuation of tyrosine kinase signaling. PTEN expression is increased by p53, and its function is blunted in seve