PTEN gene expression is regulated by hypermethylation of DNA in colon cancer cell line
β Scribed by Mitsunori Honda; Toshifumi Ashida; Mikihiro Fujiya; Kaori Fujiya; Jiro Watari; Hiroyuki Saitoh; Atsuo Maemoto; Takanori Fujiki; Fumika Orii; Yusuke Saitoh; Takeshi Obara; Yutaka Kohgo
- Book ID
- 119425380
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 343 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0016-5085
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Down-regulation of the cell-surface adhesion molecule CD44 has been suggested to play an important role in tumor progression and metastasis of prostate cancer. CD44 is encoded by a gene that contains a CpG-rich region (CpG island) in its 5Π regulatory sequence. We tried to assess whether hypermethyl