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Psychotropic effects of enalapril maleate in normal volunteers

โœ Scribed by D. Olajide; M. Lader

Publisher
Springer
Year
1985
Tongue
English
Weight
224 KB
Volume
86
Category
Article
ISSN
0033-3158

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โœฆ Synopsis

In order to establish any psychotropic effects of the angiotensin-converting enzyme inhibitor enalapril, the drug was administered in doses of 20 mg every morning for 14 days to 12 normal subjects, and compared with placebo on a battery of physiological, psychological and subjective tests, before and after the dose on the 1st and 14th days.

Diastolic blood pressure was significantly reduced and heart-rate increased by enalapril as compared with placebo; one component (P1--N1) of the auditory evoked EEG response was increased and tapping rate quickened. The commonest side effect was tiredness.

It was concluded that enalapril (unlike most other antihypertensive agents) did not lower mood but could enhance attention and alertness.

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Pharmacokinetics of repeated single oral
Pharmacokinetics of repeated single oral doses of enalapril maleate (mk-421) in normal volunteers
โœ Dr. Alice E. Till; Hector J. Gomez; Martin Hichens; James A. Bolognese; W. R. Mc ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 372 KB ๐Ÿ‘ 2 views

Enalapril, the ethyl ester of a potent angiotensin converting enzyme inhibitor, enalaprilat, was administered to healthy volunteers as a capsule containing 10 mg of the maleate salt, every 24h for eight doses. Serum profiles show little accumulation of enalaprilat following eight daily doses of enal