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Psoriasis vulgaris treated successfully with mycophenolate mofetil

✍ Scribed by Haufs; Beissert; Grabbe; SchÜtte; Luger

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
290 KB
Volume
138
Category
Article
ISSN
0007-0963

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✦ Synopsis

Mycophenolate mofetil (MMF) is a new immunosuppressive drug which non-competitively and reversibly blocks the de novo synthesis of guanine nucleotides required for DNA and RNA synthesis during T- and B-cell proliferation. This induces a selective inhibition of lymphocyte proliferation. Thus MMF is currently used to prolong graft survival in renal transplant patients. In this communication we describe the first case of a man with severe psoriasis treated successfully with oral MMF without short-term side-effects. The psoriasis area and severity index score decreased during therapy (5 weeks) from 22.0 to 11.4. Thus MMF appears to be an effective therapeutic alternative in the treatment of severe psoriasis.

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Mycophenolic acid area under the curve c
Mycophenolic acid area under the curve correlates with disease activity in lupus patients treated with mycophenolate mofetil
✍ Noël Zahr; Laurent Arnaud; Pierre Marquet; Julien Haroche; Nathalie Costedoat-Ch 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 151 KB 👁 1 views

Objective. Mycophenolic acid (MPA) is the active metabolite of mycophenolate mofetil (MMF), which is widely used to treat systemic lupus erythematosus (SLE). In transplantation, MPA area under the plasma concentration-time curve from 0 to 12 hours (MPA AUC 0-12 ) is correlated with clinical outcome.