✦ LIBER ✦

Pseudoprolines (ΨPro) in Drug Design: Direct Insertion of ΨPro Systems into Cyclosporin C

✍ Scribed by Michael Keller; Torsten Wöhr; Pascal Dumy; Luc Patiny; Manfred Mutter

Book ID: 101376744
Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 120 KB
Volume: 6
Category: Article
ISSN: 0947-6539
DOI: 10.1002/1521-3765(20001201)6:23<4358::aid-chem4358>3.0.co;2-w

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Pseudo-prolines (ΨPro): direct insertion

Pseudo-prolines (ΨPro): direct insertion of ΨPro systems into cysteine containing peptides

✍ Jean-François Guichou; Luc Patiny; Manfred Mutter 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 63 KB

The direct conversion of cysteine (Cys) containing peptides into conformationally constrained pseudo-proline (CPro) derivatives by intraresidual N,S-acetalisation has been achieved. This post-synthetic modification represents a versatile tool in structure-activity studies of bioactive peptides as ex