✦ LIBER ✦

Pseudo-prolines (ΨPro): direct insertion of ΨPro systems into cysteine containing peptides

✍ Scribed by Jean-François Guichou; Luc Patiny; Manfred Mutter

Book ID: 104251173
Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 63 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00755-4

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✦ Synopsis

The direct conversion of cysteine (Cys) containing peptides into conformationally constrained pseudo-proline (CPro) derivatives by intraresidual N,S-acetalisation has been achieved. This post-synthetic modification represents a versatile tool in structure-activity studies of bioactive peptides as exemplified for the immunosuppressive cyclosporine A (CsA) analogue [D-Cys] 8 CsA.

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