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Pseudoprolines: Targeting a cis Conformation in a Mimetic of the gp120 V3 Loop of HIV-1

✍ Scribed by Angela Wittelsberger; Michael Keller; Leo Scarpellino; Luc Patiny; Hans Acha-Orbea; Manfred Mutter

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 143 KB
Volume: 39
Category: Article
ISSN: 0044-8249
DOI: 10.1002/(sici)1521-3773(20000317)39:6<1111::aid-anie1111>3.0.co;2-d

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✦ Synopsis

Pseudoprolines (YPro) have been introduced recently as synthetic proline analogues readily obtained by cyclocondensation of the amino acids cysteine, threonine, or serine with aldehydes or ketones. [1] Their application as structure-disrupting, solubilizing protecting groups in solid-phase peptide synthesis [2,3] was followed by conformational investigations concerning the YPro preceding peptide bond. [4,5] In fact, the propensity of the amino acid proline for forming a Xaa iÀ1 -Pro

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