LAV44 and LAV15 (lymphadenopathy-associated virus) peptides of the CD4-binding region of gp 120 per se bind to the CD4 receptor (Reed and Kinzel, Biochemistry 30: 4521-4528, 1991; Lasky et al., Cell 50:975-985, 1987). Depending on the environment, the LAV peptides exhibit the ability to switch coope
✦ LIBER ✦
The Active Core in a Triazole Peptide Dual-Site Antagonist of HIV-1 gp120
✍ Scribed by Dr. Muddegowda Umashankara; Karyn McFadden; Isaac Zentner; Dr. Arne Schön; Dr. Srivats Rajagopal; Ferit Tuzer; Syna A. Kuriakose; Dr. Mark Contarino; Dr. Judith LaLonde; Prof. Ernesto Freire; Prof. Irwin Chaiken
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 835 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1860-7179
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✦ Synopsis
Supporting information for this article is available on the WWW under http://dx.doi.org/10.1002/cmdc.201000222: I. MALDI-TOF MS and RP-HPLC analysis for all reported peptides; II. Competition ELISAs, antiviral assays, and SPR sensorgrams for all reported peptides.
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