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Psammaplysin H, a new antimalarial bromotyrosine alkaloid from a marine sponge of the genus Pseudoceratina

✍ Scribed by Min Xu; Kathy T. Andrews; Geoff W. Birrell; Truc Linh Tran; David Camp; Rohan A. Davis; Ronald J. Quinn

Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
233 KB
Volume
21
Category
Article
ISSN
0960-894X

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✦ Synopsis

Mass-directed isolation of the CH 2 Cl 2 /CH 3 OH extract from a marine sponge of the genus Pseudoceratina resulted in the purification of a new antimalarial bromotyrosine alkaloid, psammaplysin H (1), along with the previously isolated analogs psammaplysins G (2) and F (3). The structure of 1 was elucidated following 1D and 2D NMR, and MS data analysis. All compounds were tested in vitro against the 3D7 line of Plasmodium falciparum and mammalian cell lines (HEK293 and HepG2), with 1 having the most potent (IC 50 0.41 lM) and selective (>97-fold) antimalarial activity.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Psammaplysin H, a N
ChemInform Abstract: Psammaplysin H, a New Antimalarial Bromotyrosine Alkaloid from a Marine Sponge of the Genus Pseudoceratina.
✍ Min Xu; Kathy T. Andrews; Geoff W. Birrell; Truc Linh Tran; David Camp; Rohan A. πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons βš– 36 KB πŸ‘ 2 views

## Abstract Mass‐directed isolation of the large‐scale CH~2~Cl~2~/Me‐OH extract from the title sponge affords the new alkaloid psammaplysin H (I) together with the previously isolated analogues psammaplysins G and F.