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Protonated state of methotrexate, trimethoprim, and pyrimethamine bound to dihydrofolate reductase

✍ Scribed by Lennie Cocco; Barbara Roth; Carroll Temple Jr.; John A. Montgomery; Robert E. London; Raymond L. Blakley

Book ID
115705720
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
905 KB
Volume
226
Category
Article
ISSN
0003-9861

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Dynamics of trimethoprim bound to dihydr
Dynamics of trimethoprim bound to dihydrofolate reductaseβ€”a deuterium NMR study
✍ Qing-Xian Yang; Fu-Yung Huang; Ta-Hsien Lin; Leslie Gelbaum; Elizabeth E. Howell πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 792 KB

We have employed deuterium NMR techniques to determine the dynamics of trimethoprim (TMP) in a binary complex with dihydrofolate reductase (DHFR) or in a ternary complex with DHFR and cofactor NADP+ in the fully hydrated state. TMP was deuterated at the following positions: (2',6'-D2)TMP, (3'-Ome-D3