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Dynamics of Trimethoprim Bound to Dihydrofolate Reductase

✍ Scribed by M. S. Searle, M. J. Forster, B. Birdsall, G. C. K. Roberts, J. Feeney, H. T. A. Cheung, I. Kompis and A. J. Geddes

Book ID
123635506
Publisher
National Academy of Sciences
Year
1988
Tongue
English
Weight
977 KB
Volume
85
Category
Article
ISSN
0027-8424

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πŸ“œ SIMILAR VOLUMES

Dynamics of trimethoprim bound to dihydr
Dynamics of trimethoprim bound to dihydrofolate reductaseβ€”a deuterium NMR study
✍ Qing-Xian Yang; Fu-Yung Huang; Ta-Hsien Lin; Leslie Gelbaum; Elizabeth E. Howell πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 792 KB

We have employed deuterium NMR techniques to determine the dynamics of trimethoprim (TMP) in a binary complex with dihydrofolate reductase (DHFR) or in a ternary complex with DHFR and cofactor NADP+ in the fully hydrated state. TMP was deuterated at the following positions: (2',6'-D2)TMP, (3'-Ome-D3