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Proton-Transfer Dynamics in the Activation of Cytochrome P450eryF

โœ Scribed by Guallar, Victor; Harris, Danni L.; Batista, Victor S.; Miller, William H.


Book ID
126461338
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
182 KB
Volume
124
Category
Article
ISSN
0002-7863

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A strongly conserved threonine residue in the I-helix of cytochrome P450 enzymes participates in a proton delivery system for binding and cleavage of dioxygen molecules. 6-Deoxyerythronol ide B hydroxylase (P450eryF) is unusual in that the conserved threonine residue is replaced by alanine in this e