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Proton-Detected Solid-State NMR Spectroscopy of Natural-Abundance Peptide and Protein Pharmaceuticals

✍ Scribed by Donghua H. Zhou; Gautam Shah; Charles Mullen; Dennis Sandoz; Chad M. Rienstra

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 581 KB
Volume: 48
Category: Article
ISSN: 0044-8249
DOI: 10.1002/anie.200801029

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✦ Synopsis

Abstract

The natural way: A sensitive NMR spectroscopic method is developed to obtain well‐resolved two‐dimensional spectra (^15^N–^1^H and ^13^C–^1^H) for natural‐abundance (that is, without the need for isotopic enrichment) large‐molecule samples, such as biopharmaceuticals. This method gives structural insights on two lyophilized aprotinin samples and three insulin samples in lyophilized, microcrystalline suspension formulation (red; see picture) and fibril (green) forms.magnified image

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