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Proteopedia entry: Phosphoinositide 3-kinase

✍ Scribed by David Canner

Publisher
The American Society for Biochemistry and Molecular Biology
Year
2011
Tongue
English
Weight
97 KB
Volume
39
Category
Article
ISSN
1470-8175

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The rapid and accurate response of leukocytes to environmental cues is critical for a proper inflammatory reaction to foreign particles or invading microbes. In the last decade, the signal transduction enzyme phosphoinositide 3-kinase c (PI3Kc) has emerged as a critical modulator of leukocyte respon

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Phosphoinositide 3-kinase promotes adult subventricular neuroblast migration after stroke
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## Abstract Rodent adult subventricular zone (SVZ)‐derived progenitor cells abandon the rostral migratory stream (RMS)/olfactory complex postmiddle cerebral artery occlusion (MCAo) and migrate into compromised tissue, possibly playing a role in brain recovery. Using SVZ tissue explants from the adu

Ligands of CD4 inhibit the association o
Ligands of CD4 inhibit the association of phospholipase CΞ³1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity
✍ SΓ©bastien Jauliac; Fabienne Mazerolles; Nada Jabado; AnnaΓ―ck Pallier; FrΓ©dΓ©ric B πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 136 KB πŸ‘ 1 views

We have previously shown that CD4 ligands inhibit interleukin-2 (IL-2) production and T cell proliferation in human peripheral CD4 + T lymphocytes, in an MHC-independent way. Two major pathways implicated in T cell activation are inhibited by binding of CD4 ligands to the CD4 molecule, i. e. Ca 2+ s

Leukocytes on the move with phosphoinosi
Leukocytes on the move with phosphoinositide 3-kinase and its downstream effectors
✍ Erik Procko; Shaun R. McColl πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 272 KB

Cell signalling mediators derived from membrane phospholipids are frequent participants in biological processes. The family of phosphoinositide 3-kinases (PI3Ks) phosphorylate the membrane lipid phosphatidylinositol, generating second messengers that direct diverse responses. These PI3K products are