We have previously shown that CD4 ligands inhibit interleukin-2 (IL-2) production and T cell proliferation in human peripheral CD4 + T lymphocytes, in an MHC-independent way. Two major pathways implicated in T cell activation are inhibited by binding of CD4 ligands to the CD4 molecule, i. e. Ca 2+ s
Regulation of phosphoinositide 3-kinase γ protein kinase activity in vitro and in COS-7 cells
✍ Scribed by Andrey Bondev; Tzvetanka Bondeva; Reinhard Wetzker
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 478 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1615-4053
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Several growth factors, such as vascular endothelial growth factor, brain‐derived neurotrophic factor, and insulin‐like growth factor‐I are involved in the actions of progesterone in the central nervous system. Previous studies in neuronal and glial cultures have shown that progesterone
## Abstract The effects of P2Y2 purinoceptor activation on c‐Fos expression and the signaling pathways evoked by extracellular ATP/UTP in HeLa cells were investigated. We found that P2Y2 activation induced c‐Fos protein and phosphorylated the extracellular signal‐regulated kinases 1 and 2 (ERK1/2).
## Abstract All‐trans retinoic acid (ATRA), a synthetic derivative of vitamin A, inhibits the growth of breast cancer cells. To elucidate the mechanism by which ATRA causes cell growth inhibition, we examined changes in cell cycle and intracellular signaling pathways, focusing on protein kinase C (
## Abstract We have earlier shown that oral infusion of a polyphenolic fraction isolated from green tea, at a human achievable dose (equivalent to six cups of green tea per day), significantly inhibits prostate cancer (PCA) development and metastasis in __tr__ansgenic __a__denocarcinoma of __m__ous
## Abstract Mitogen‐associated protein kinase (MAPK)‐ and protein kinase A (PKA)‐dependent signal transductions play important roles in the regulation of gene expression. Both MAPK and PKA pathways can be activated by light exposure. In this study, we investigated the effect of light on MAPK and PK