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Proteomic identification of proteins specifically oxidized by intracerebral injection of amyloid β-peptide (1–42) into rat brain: Implications for Alzheimer’s disease

✍ Scribed by D. Boyd-Kimball; R. Sultana; H. Fai Poon; B.C. Lynn; F. Casamenti; G. Pepeu; J.B. Klein; D.A. Butterfield


Book ID
116786855
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
582 KB
Volume
132
Category
Article
ISSN
0306-4522

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Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by loss of memory and cognition and by senile plaques and neurofibrillary tangles in brain. Amyloid-beta peptide, particularly the 42-amino-acid peptide (Abeta(1-42)), is a principal component of senile plaques and is