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Proteomic Analysis of the Resistance to Aplidin in Human Cancer Cells

✍ Scribed by González-Santiago, Laura; Alfonso, Patricia; Suárez, Yajaira; Núñez, Antonio; García-Fernández, Luis F.; Alvarez, Enrique; Muñoz, Alberto; Casal, J. Ignacio

Book ID
118739276
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
701 KB
Volume
6
Category
Article
ISSN
1535-3893

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## Abstract In order to understand the molecular mechanisms of multidrug resistance (MDR) in ovarian cancer, we employed the proteomic approach of isobaric tags for relative and absolute quantification (iTRAQ), followed by LC‐MS/MS, using the cisplatin‐resistant COC1/DDP cell line and its parental