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Proteomic alterations in primary rat hepatocytes induced by methapyrilene

✍ Scribed by Tanja Heise; Markus Schug; Christine Meckert; Georgia Günther; Alfonso Lampen; Jan G. Hengstler; Axel Oberemm


Book ID
116925611
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
101 KB
Volume
211
Category
Article
ISSN
0378-4274

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DNA methylation and oncogene expression
✍ Lidia Hernandez; Christos J. Petropoulos; Stephen H. Hughes; William Lijinsky 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 654 KB

Continued exposure of rats to carcinogenic doses of methapyrilene (MP) leads to elevated levels of 5-methyl-deoxycytidine (5MC) in liver DNA. Since gene expression often correlates with DNA methylation, we investigated these parameters in the MP-induced hepatocellular carcinomas of Fischer 344 rats.