✦ LIBER ✦

Solved in vivo/in vitro discrepancy in methapyrilene induced gene alterations in rat liver and in collagen sandwich cultured primary rat hepatocytes

✍ Scribed by Markus Schug; Tanja Heise; Georgia Günther; Dorothe Storm; Axel Oberemm; Jan G. Hengstler

Book ID: 119381101
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 70 KB
Volume: 189
Category: Article
ISSN: 0378-4274
DOI: 10.1016/j.toxlet.2009.06.231

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Pharmacokinetics explain in vivo/in vitr

Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes

✍ Markus Schug, Regina Stöber, Tanja Heise, Hans Mielke, Ursula Gundert-Remy, Patr 📂 Article 📅 2012 🏛 Springer-Verlag 🌐 English ⚖ 447 KB

Comparison of hepatocarcinogen-induced g

Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver

✍ Tatyana Y. Doktorova, Heidrun Ellinger-Ziegelbauer, Mathieu Vinken, Tamara Vanha 📂 Article 📅 2012 🏛 Springer-Verlag 🌐 English ⚖ 871 KB

DNA methylation and oncogene expression

DNA methylation and oncogene expression in methapyrilene-induced rat liver tumors and in treated hepatocytes in culture

✍ Lidia Hernandez; Christos J. Petropoulos; Stephen H. Hughes; William Lijinsky 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 654 KB

Continued exposure of rats to carcinogenic doses of methapyrilene (MP) leads to elevated levels of 5-methyl-deoxycytidine (5MC) in liver DNA. Since gene expression often correlates with DNA methylation, we investigated these parameters in the MP-induced hepatocellular carcinomas of Fischer 344 rats.

Synergistic Induction by Collagen and Fi

Synergistic Induction by Collagen and Fibronectin of Liver-Specific Genes in Rat Primary Cultured Hepatocytes

✍ Hisako Ouchi; Kaoru Otsu; Takejiro Kuzumaki; Yoshihito Iuchi; Kiichi Ishikawa 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 156 KB

Interactions between metallothionein ind

Interactions between metallothionein inducers in rat liver and primary cultures of rat hepatocytes

✍ J. Hernandez; M. Giralt; E. Belloso; D.V. Rebollo; B. Romero; J. Hidalgo 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 627 KB

Differential regulation of P-glycoprotei

Differential regulation of P-glycoprotein genes in primary rat hepatocytes by collagen sandwich and drugs

✍ Chow H. Lee 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 146 KB 👁 1 views

P-glycoprotein (Pgp) is a small family of plasma membrane proteins, which are capable of transporting substrates across cell membranes. Class I and II Pgp are able to transport drugs and have been shown to mediate multidrug resistance (MDR). Class III Pgp is a long chain phospholipid transporter and