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Proteome-wide Profiling of Isoniazid Targets in Mycobacterium tuberculosis†

✍ Scribed by Argyrou, Argyrides; Jin, Lianji; Siconilfi-Baez, Linda; Angeletti, Ruth H.; Blanchard, John S.

Book ID
115543629
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
151 KB
Volume
45
Category
Article
ISSN
0006-2960

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The preferred antitubercular drug isoniazid specifically targets a long-chain enoyl-acyl carrier protein reductase (InhA), an enzyme essential for mycolic acid biosynthesis in__Mycobacterium tuberculosis__. Despite the widespread use of this drug for more than 40 years, its precise mode of action ha