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Proteome-wide Analysis of Chaperonin-Dependent Protein Folding in Escherichia coli

✍ Scribed by Michael J. Kerner; Dean J. Naylor; Yasushi Ishihama; Tobias Maier; Hung-Chun Chang; Anna P. Stines; Costa Georgopoulos; Dmitrij Frishman; Manajit Hayer-Hartl; Matthias Mann; F. Ulrich Hartl

Book ID
116352660
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
616 KB
Volume
122
Category
Article
ISSN
0092-8674

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Many heterologous polypeptides fail to fold into their native state when expressed in Escherichia co~i; instead, they are either degraded by the cellular proteolytic machinery or accumulate in insoluble form, typically as inclusion bodies. Misfolding is a particularly vexing problem in the expressio