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Proteolytic cleavage of the Alzheimer's disease amyloid beta precursor protein

✍ Scribed by Ishiura, Shoichi; Tagawa, Kazuhiko; Maruyama, Kei; Suzuki, Koichi

Book ID
122873003
Publisher
Elsevier Science
Year
1992
Weight
97 KB
Volume
17
Category
Article
ISSN
0921-8696

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## Abstract Proteolytic processing of the amyloid precursor protein by Ξ² ‐and γ‐secretases results in the production of Alzheimer's disease (AD) AΞ² amyloid peptides. Modulation of secretase activity is being investigated as a potential therapeutic approach. Recent studies with human brain have reve