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Proteinase 3 sidesteps caspases and cleaves p21Waf1/Cip1/Sdi1 to induce endothelial cell apoptosis

✍ Scribed by Pendergraft, William F.; Rudolph, Earl H.; Falk, Ronald J.; Jahn, Jennifer E.; Grimmler, Matthias; Hengst, Ludger; Jennette, J. Charles; Preston, Gloria A.

Book ID: 109065254
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 266 KB
Volume: 65
Category: Article
ISSN: 0085-2538
DOI: 10.1111/j.1523-1755.2004.00364.x

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Codon 273 is one of the hot spots of missense mutation of the p53 tumor suppressor gene found in human cancers. We have previously reported that a mutation at codon 273, p53-273L (Arg 3 Leu), suppresses cell growth despite its having no p53-specific transactivation activity. To further elucidate the