Protein Tyrosine Kinases Associated with Human Malignancies
β Scribed by PAOLO M. COMOGLIO; MARIA FLAVIA DI RENZO; GIOVANNI GAUDINO
- Book ID
- 119859947
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 363 KB
- Volume
- 511
- Category
- Article
- ISSN
- 0890-6564
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Protein tyrosine kinase (PTK) activity associated with synaptosomal membrane glycoprotein (SMGP) fractions of rat brain was examined. The synthetic substrate poly(Glu,-Tyr) was phosphorylated by SMGP in the presence of Mg2+ and Mn2+, whose stimulatory effects were additive. In contrast, endogenous t
A tyrosine protein kinase activity has been detected in the mitochondrial fraction purified from human fibroblasts. By enzymatic and sedimentation analysis this activity appeared to be localized in the mitochondrial outer membrane. Mitochondrial tyrosine phosphorylation was strictly dependent on the