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Protein structure prediction

โœ Scribed by David R Westhead; Janet M Thornton


Book ID
104362092
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
524 KB
Volume
9
Category
Article
ISSN
0958-1669

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โœฆ Synopsis


Genome sequencing projects continue to provide a flood of new protein sequences, and prediction methods remain an important means of adding structural information. Recently, there have been advances in secondary structure prediction, which feed, in turn, into improved fold recognition algorithms. Finally, there have been technical improvements in comparative modelling, and studies of the expected accuracy of three-dimensional structural models built by this method.


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## Abstract This review presents the advances in protein structure prediction from the computational methods perspective. The approaches are classified into four major categories: comparative modeling, fold recognition, first principles methods that employ database information, and first principles