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Protein Recognition by an Ensemble of Fluorescent DNA G-Quadruplexes

✍ Scribed by David Margulies; Andrew D. Hamilton

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
549 KB
Volume
48
Category
Article
ISSN
0044-8249

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✦ Synopsis

Abstract

Sniffing out proteins: Fluorescent DNA G‐quadruplexes have been used for building versatile signaling receptors for proteins in a single solution. Introducing a protein sample to the ensemble results in a unique emission signature for unambiguous identification (see scheme, R=fluorophore). The self‐assembled, pattern‐based protein detection systems are easily fabricated, have the potential for high‐throughput operations, and have the ability to handle small protein samples.magnified image

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