Protein-Protein Interactions

✍ Scribed by Michael D. Wendt (auth.), Michael D. Wendt (eds.)

Publisher: Springer-Verlag Berlin Heidelberg
Year: 2012
Tongue: English
Leaves: 276
Series: Topics in Medicinal Chemistry 8
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

Michael D. Wendt
Protein-Protein Interactions as Drug Targets

Shaomeng Wang , Yujun Zhao , Denzil Bernard , Angelo Aguilar , Sanjeev Kumar
Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapeutics

Kurt Deshayes , Jeremy Murray , Domagoj Vucic
The Development of Small-Molecule IAP Antagonists for the Treatment of Cancer

John F. Kadow , David R. Langley , Nicholas A. Meanwell , Michael A. Walker , Kap-Sun Yeung , Richard Pracitto
Protein-Protein Interaction Targets to Inhibit HIV-1 Infection

Nicholas A. Meanwell , David R. Langley
Inhibitors of Protein-Protein Interactions in Paramyxovirus Fusion – a Focus on Respiratory Syncytial Virus

Andrew B. Mahon , Stephen E. Miller , Stephen T. Joy , Paramjit S. Arora
Rational Design Strategies for Developing Synthetic Inhibitors of Helical Protein Interfaces

Michael D. Wendt
The Discovery of Navitoclax, a Bcl-2 Family Inhibitor

✦ Table of Contents

Front Matter....Pages i-xviii
Protein-Protein Interactions as Drug Targets....Pages 1-55
Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapeutics....Pages 57-79
The Development of Small-Molecule IAP Antagonists for the Treatment of Cancer....Pages 81-103
Protein-Protein Interaction Targets to Inhibit HIV-1 Infection....Pages 105-165
Inhibitors of Protein-Protein Interactions in Paramyxovirus Fusion: A Focus on Respiratory Syncytial Virus....Pages 167-196
Rational Design Strategies for Developing Synthetic Inhibitors of Helical Protein Interfaces....Pages 197-230
The Discovery of Navitoclax, a Bcl-2 Family Inhibitor....Pages 231-258
Back Matter....Pages 259-261

✦ Subjects

Chemistry/Food Science, general

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