Protein phosphatase type 2A, PP2A, is involved in degradation of gp130
β Scribed by Shinya Mitsuhashi; Hiroshi Shima; Nobuhiro Tanuma; Sumie Sasa; Kazunori Onoe; Makoto Ubukata; Kunimi Kikuchi
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 163 KB
- Volume
- 269
- Category
- Article
- ISSN
- 0300-8177
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Protein phosphatase 2Aa (PP-2Aa) is one of the catalytic subunits of PP-2A, which is composed of catalytic and regulatory subunits. In fission yeasts, PP-2A mutants cause mitotic defects and strikingly different cell cycle phenotypes. In rat hepatocellular carcinomas, mRNA expression of PP-2Aa was i
We examined the effects of okadaic acid, a protein phosphatase 1 and 2A inhibitor, on superoxide generation in human neutrophils. Superoxide generation induced by fMLP was inhibited by low-dose okadaic acid (1 0-1 00 nM), but it had no effect on superoxide synthesis by PMA, and the fMLP-induced rise