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Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways

✍ Scribed by Takekawa, M.

Book ID: 119770260
Publisher: Nature Publishing Group
Year: 1998
Tongue: English
Weight: 322 KB
Volume: 17
Category: Article
ISSN: 0261-4189
DOI: 10.1093/emboj/17.16.4744

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## Abstract Fas and FasL expression upregulation was found in human leukemia K562 cells upon exposure to __Naja naja atra__ phospholipase A~2~ (PLA~2~). PLA~2~ treatment induced an increase in intracellular Ca^2+^ ([Ca^2+^]i) and ROS generation levels, leading to activation of p38 MAPK and JNK. Sup