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Notexin upregulates Fas and FasL protein expression of human neuroblastoma SK-N-SH cells through p38 MAPK/ATF-2 and JNK/c-Jun pathways

โœ Scribed by Ku-Chung Chen; Long-Sen Chang

Book ID
116922535
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
917 KB
Volume
55
Category
Article
ISSN
0041-0101

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## Abstract Fas and FasL expression upregulation was found in human leukemia K562 cells upon exposure to __Naja naja atra__ phospholipase A~2~ (PLA~2~). PLA~2~ treatment induced an increase in intracellular Ca^2+^ ([Ca^2+^]i) and ROS generation levels, leading to activation of p38 MAPK and JNK. Sup