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Protein phosphatase-2A regulates protein tyrosine phosphatase activity in Lewis lung carcinoma tumor variants

✍ Scribed by Jodi L. Jackson; M. Rita I. Young

Book ID: 111538360
Publisher: Springer
Year: 2003
Tongue: English
Weight: 191 KB
Volume: 20
Category: Article
ISSN: 0262-0898
DOI: 10.1023/a:1024012000009

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## Abstract Compared to metastatic Lewis lung carcinoma (LLC) cells, nonmetastatic LLC cells have increased levels of activity of the protein phosphatase PP‐2A, which functions to limit their migration through transwell chambers. Inhibition of PP‐2A in nonmetastatic LLC stimulates their transmigrat