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Protein Misfolding, Functional Amyloid, and Human Disease

✍ Scribed by Chiti, Fabrizio; Dobson, Christopher M.


Book ID
111891820
Publisher
Annual Reviews
Year
2006
Tongue
English
Weight
589 KB
Volume
75
Category
Article
ISSN
0066-4154

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Protein Misfolding and Human Disease
✍ Gregersen, Niels; Bross, Peter; Vang, SΓΈren; Christensen, Jane H. πŸ“‚ Article πŸ“… 2006 πŸ› Annual Reviews 🌐 English βš– 694 KB
Protein Misfolding and Human Disease
✍ Gregersen, Niels; Bross, Peter; Vang, SΓΈren; Christensen, Jane H. πŸ“‚ Article πŸ“… 2006 πŸ› Annual Reviews 🌐 English βš– 694 KB

Protein misfolding is a common event in living cells. In young and healthy cells, the misfolded protein load is disposed of by protein quality control (PQC) systems. In aging cells and in cells from certain individuals with genetic diseases, the load may overwhelm the PQC capacity, resulting in accu