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Protein Misfolding and Human Disease

✍ Scribed by Gregersen, Niels; Bross, Peter; Vang, Søren; Christensen, Jane H.


Book ID
120284681
Publisher
Annual Reviews
Year
2006
Tongue
English
Weight
694 KB
Volume
7
Category
Article
ISSN
1527-8204

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Protein Misfolding and Human Disease
✍ Gregersen, Niels; Bross, Peter; Vang, Søren; Christensen, Jane H. 📂 Article 📅 2006 🏛 Annual Reviews 🌐 English ⚖ 694 KB

Protein misfolding is a common event in living cells. In young and healthy cells, the misfolded protein load is disposed of by protein quality control (PQC) systems. In aging cells and in cells from certain individuals with genetic diseases, the load may overwhelm the PQC capacity, resulting in accu