Protein Misfolding and Human Disease
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Gregersen, Niels; Bross, Peter; Vang, Søren; Christensen, Jane H.
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Article
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2006
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Annual Reviews
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English
⚖ 694 KB
Protein misfolding is a common event in living cells. In young and healthy cells, the misfolded protein load is disposed of by protein quality control (PQC) systems. In aging cells and in cells from certain individuals with genetic diseases, the load may overwhelm the PQC capacity, resulting in accu