Protein Mimicry: A New Dimension for Peptides as Lead Compounds?

✍ Scribed by Ulrich Reineke; Jens Schneider-Mergener

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 116 KB
• Volume: 37
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/(sici)1521-3773(19980403)37:6<769::aid-anie769>3.0.co;2-b

✦ Synopsis

A short peptide as mimic for the hemopoietic growth factor erythropoietin (containing 165 amino acids) could be identified with the aid of peptide libraries on phage surfaces (phage display). The crystal structure of a peptide dimer complexed with two erythropoietin receptors (shown on the right) provides an insight into the molecular basis of this protein mimicry.