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Protein kinase D activation stimulates the transcription of the insulin receptor gene

✍ Scribed by Hao Zhang; Wei-Jia Kong; Yong-Qiang Shan; Dan-Qing Song; Yi Li; Yue-Ming Wang; Xue-Fu You; Jian-Dong Jiang


Book ID
116734868
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
665 KB
Volume
330
Category
Article
ISSN
0303-7207

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## Abstract Treatment with 10^βˆ’8^ m 1,25‐dihydroxyvitamin D~3~ for 24 h causes transcriptional activation of the human insulin receptor gene in U‐937 human promonocytic cells. The activation seems to potentiate the response to insulin in terms of glucose oxidation. Wortmannin, a phosphatidylinosito