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Protein kinase C α trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2

✍ Scribed by Wu Wen-Sheng

Book ID: 116333916
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 267 KB
Volume: 239
Category: Article
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2005.07.034

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## Abstract MCF‐ 10A is a spontaneously immortalized, non‐transformed human mammary epithelial cell line. We have recently obtained MCF‐ 10A clones (MCF‐ 1OA HE cells) that are transformed following over‐expression of both a human point‐mutated c‐Ha‐__ras__ and the c‐__erb__B‐2 proto‐oncogenes. Two