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Reduction of RIα Subunit of cAMP-dependent Protein Kinase Expression Induces Growth Inhibition of Human Mammary Epithelial Cells Transformed by TGF-α, c-Ha-ras, and c-erbB-2 Genes

✍ Scribed by FORTUNATO CIARDIELLO; GIAMPAOLO TORTORA; STEFANO PEPE; CATERINA BIANCO; GUSTAVO BALDASSARRE; ANGELA RUGGIERO; CATALDO BIANCO; MOUNA P. SELVAM; A. RAFFAELE BIANCO

Book ID: 119868204
Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 354 KB
Volume: 698
Category: Article
ISSN: 0890-6564
DOI: 10.1111/j.1749-6632.1993.tb17194.x

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## Abstract MCF‐ 10A is a spontaneously immortalized, non‐transformed human mammary epithelial cell line. We have recently obtained MCF‐ 10A clones (MCF‐ 1OA HE cells) that are transformed following over‐expression of both a human point‐mutated c‐Ha‐__ras__ and the c‐__erb__B‐2 proto‐oncogenes. Two