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Protein kinase C and amyloid precursor protein processing in skin fibroblasts from sporadic and familial Alzheimer’s disease cases

✍ Scribed by Monika Vestling; Ángel Cedazo-Mı́nguez; Abdu Adem; Birgitta Wiehager; Marco Racchi; Lars Lannfelt; Richard F. Cowburn


Book ID
117618391
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
316 KB
Volume
1453
Category
Article
ISSN
0925-4439

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## Abstract Proteolytic processing of the amyloid precursor protein by β ‐and γ‐secretases results in the production of Alzheimer's disease (AD) Aβ amyloid peptides. Modulation of secretase activity is being investigated as a potential therapeutic approach. Recent studies with human brain have reve