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Protein Kinase C Activation Reduces the Function of the Na+:K+:2Cl− Cotransporter in Xenopus laevis Oocytes

✍ Scribed by Consuelo Plata; Verena Rubio; Gerardo Gamba


Book ID
114180240
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
131 KB
Volume
31
Category
Article
ISSN
0188-4409

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Protein kinase C activation downregulate
✍ Omid C. Farokhzad; G.D. Vivek Sagar; Edward C. Mun; Jason K. Sicklick; Margaret 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 251 KB

The basolateral Na ϩ /K ϩ /2Cl Ϫ cotransporter (NKCC1) has been shown to be an independent regulatory site for electrogenic Cl Ϫ secretion. The proinflammatory phorbol ester, phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), inhibits basal and cyclic adenosine monophosph