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Na+–K+–2Cl− cotransporter type 2 trafficking and activity: The role of interacting proteins

✍ Scribed by Monica Carmosino; Giuseppe Procino; Maria Svelto


Book ID
114675209
Publisher
Portland Press
Year
2012
Tongue
English
Weight
217 KB
Volume
104
Category
Article
ISSN
0248-4900

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The basolateral Na ϩ /K ϩ /2Cl Ϫ cotransporter (NKCC1) has been shown to be an independent regulatory site for electrogenic Cl Ϫ secretion. The proinflammatory phorbol ester, phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), inhibits basal and cyclic adenosine monophosph