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Protein kinase C activation blocks calcium receptor signaling in Xenopus laevis oocytes

✍ Scribed by Wenhan Chang; Stacy Pratt; Tsui-Hua Chen; Dolores Shoback


Book ID
117464316
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
204 KB
Volume
158
Category
Article
ISSN
0303-7207

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Inactivation of Ca2(+)-induced Cl- currents was studied in Xenopus oocytes using the two-electrode voltage-clamp technique. In oocytes permeabilized to Ca2+ by treatment with the ionophore A23187, Ca2+ influx caused by the addition of 2.5-5 mM Ca2+ to the extracellular solution elicited Cl- currents