Novel diphosphonate homologs 7a-7c, and their cyclic counterparts 8a-8c, of the previously synthesized farnesyl pyrophosphate analogs 1 and 2 were prepared and tested for their inhibition potency and specificity of the enzymes PFT and PGGT-I. Compound 2 was shown to be the most potent inhibitor of P
Protein isoprenylation regulates osteogenic differentiation of mesenchymal stem cells: effect of alendronate, and farnesyl and geranylgeranyl transferase inhibitors
โ Scribed by G Duque; C Vidal; D Rivas
- Book ID
- 111219756
- Publisher
- Nature Publishing Group
- Year
- 2011
- Tongue
- English
- Weight
- 925 KB
- Volume
- 162
- Category
- Article
- ISSN
- 0007-1188
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract There is a need to develop improved methods for directing and maintaining the differentiation of human mesenchymal stem cells (hMSC) for regenerative medicine. Here, we present a method for embedding cells in defined protein microenvironments for the directed osteogenic differentiation
## Abstract Valproic acid (VPA) has been used as an anticonvulsant agent for the treatment of epilepsy, as well as a mood stabilizer for the treatment of bipolar disorder, for several decades. The mechanism of action for these effects remains to be elucidated and is most likely multifactorial. Rece