Protein intake and 5-fluorouracil toxicity in tumor-bearing animals
β Scribed by Michael H. Torosian; Shailen Jalali; Hung Q. Nguyen
- Book ID
- 116010531
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 466 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0022-4804
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## Abstract Schedule dependent inhibition of thymidylate synthase (TS) and tumor growth by 5βfluorouracil (FUra) was examined in Yoshida sarcoma (YS) bearing Donryu rats. After implantation of YS cells (1 Γ 10^4^), FUra (20 mg/kg/day) was continuously (group C) or daily bolus injection (group B) ad
Three 18F-labeled pyrimidines, 18F-5-fluorouridine (18F-5-FUR), 18F-5-fluorouracil (18F-5-FU), and 18F-5-fluorodeoxyuridine (18F-5-FdUR), were examined regarding tissue distribution and tumor uptake in ascitic hepatoma AH109A-bearing rats. The differential absorption ratios of tumors of 18F-5-FUR, 1