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Protein hydrophobicity and stability support the thermodynamic theory of protein degradation

โœ Scribed by David F. Mann; Karen Shah; David Stein; Gary A. Snead


Book ID
113264727
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
418 KB
Volume
788
Category
Article
ISSN
0167-4838

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New HyTs are a knockout: we previously reported that labeling HaloTag proteins with low molecular weight hydrophobic tags (HyTs) leads to targeted degradation of HaloTag fusion proteins. In this report, we employed a chemical approach to extend this hydrophobic tagging methodology to highly stabiliz