Identification of Hydrophobic Tags for t
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Dr. Hyun Seop Tae; Dr. Thomas B. Sundberg; Dr. Taavi K. Neklesa; Devin J. Noblin
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Article
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2012
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John Wiley and Sons
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English
โ 461 KB
New HyTs are a knockout: we previously reported that labeling HaloTag proteins with low molecular weight hydrophobic tags (HyTs) leads to targeted degradation of HaloTag fusion proteins. In this report, we employed a chemical approach to extend this hydrophobic tagging methodology to highly stabiliz