Conservation of polar residues as hot sp
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Zengjian Hu; Buyong Ma; Haim Wolfson; Ruth Nussinov
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Article
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2000
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John Wiley and Sons
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English
β 394 KB
A number of studies have addressed the question of which are the critical residues at protein-binding sites. These studies examined either a single or a few protein-protein interfaces. The most extensive study to date has been an analysis of alanine-scanning mutagenesis. However, although the total