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Anatomy of hot spots in protein interfaces

✍ Scribed by Andrew A Bogan; Kurt S Thorn


Book ID
115628597
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
381 KB
Volume
280
Category
Article
ISSN
0022-2836

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A number of studies have addressed the question of which are the critical residues at protein-binding sites. These studies examined either a single or a few protein-protein interfaces. The most extensive study to date has been an analysis of alanine-scanning mutagenesis. However, although the total