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Protein Folding Transition States: Elicitation of Hammond Effects by 2,2,2-Trifluoroethanol

✍ Scribed by C.-P. Benny Yiu; Mauricio G. Mateu; Alan R. Fersht


Book ID
101353271
Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
207 KB
Volume
1
Category
Article
ISSN
1439-4227

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Theoretical studies of SN2 transition st
✍ Saul Wolfe; D.J. Mitchell; H. Bernhard Schlegel; C. Minot; O. Eisenstein πŸ“‚ Article πŸ“… 1982 πŸ› Elsevier Science 🌐 French βš– 301 KB

The quazitative HOMO-LVMO orbital interaction interpretation of the aZpha effect is found to be invaZid for anionic nucleophiles. In any event, gas phase SN2 reactions of HOO-and FO'O-show no evidence of the effect. The role of a hydroxylic solvent requires greater consideration as the source of pos